Journal: iScience

Article Title: Identification of proteotoxic and proteoprotective bacteria that non-specifically affect proteins associated with neurodegenerative diseases

doi: 10.1016/j.isci.2024.110828

Figure Lengend Snippet:

Article Snippet: Enterococcus faecium , BEI Resources , HM-968.

Techniques: Virus, Recombinant, Membrane, Western Blot, Software

Journal: Journal of medicinal chemistry

Article Title: Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity In Vitro and In Vivo against Vancomycin-resistant Enterococci

doi: 10.1021/acs.jmedchem.6b01780

Figure Lengend Snippet: Minimum inhibitory concentration (MIC 50 ) (in μg/mL) and minimum bactericidal concentration (MBC 50 ) of phenylthiazole compounds 1–3 , vancomycin, and linezolid against 50% of vancomycin-sensitive (VSE) and vancomycin-resistant Enterococcus faecalis or E. faecium (VRE) strains.

Article Snippet: Clinical isolates of E. faecalis and E. faecium were obtained through BEI Resources ( Table S1 ).

Techniques: Concentration Assay

Journal: Journal of medicinal chemistry

Article Title: Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity In Vitro and In Vivo against Vancomycin-resistant Enterococci

doi: 10.1021/acs.jmedchem.6b01780

Figure Lengend Snippet: Time-kill analysis of phenylthiazole compounds 1, 2, 3, and linezolid (all tested at 4 × MIC) over a 24 hour incubation period at 37 °C against A) vancomycin-resistant Enterococcus faecium ATCC 700221 and B) vancomycin-resistant Enterococcus faecalis HM-201. DMSO served as a negative control. The error bars represent standard deviation values obtained from triplicate samples used for each compound/antibiotic studied.

Article Snippet: Clinical isolates of E. faecalis and E. faecium were obtained through BEI Resources ( Table S1 ).

Techniques: Incubation, Negative Control, Standard Deviation

Journal: Journal of medicinal chemistry

Article Title: Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity In Vitro and In Vivo against Vancomycin-resistant Enterococci

doi: 10.1021/acs.jmedchem.6b01780

Figure Lengend Snippet: Multi-step resistance selection of compounds 1, 2, 3, and linezolid against A) vancomycin-resistant Enterococcus faecium HM-968 and B) vancomycin-resistant Enterococcus faecalis ATCC 51299. Bacteria were serially passaged over a fourteen-day period and the broth microdilution assay was used to determine the minimum inhibitory concentration of each compound against VRE after each successive passage. A four-fold shift in the MIC is defined as resistance to the test agent.

Article Snippet: Clinical isolates of E. faecalis and E. faecium were obtained through BEI Resources ( Table S1 ).

Techniques: Selection, Bacteria, Microdilution Assay, Concentration Assay